The Calculate 2D Matrix Set item of the Dosimetry menu initiates calculation of the dose matrix set as defined in the Preference Settings window for the currently active plaque or set of plaques. If this item is dimmed and can not be selected it means there are no sources in the currently active plaque. If this item is colored red it means the active plaque has sources but the dosimetry set is invalid and needs to be recalculated. If this item is colored green it means the set is valid and does not need to be recalculated.
A 2D matrix set consists of dose matrices for various surfaces; e.g. a meridian plane, a coronal plane, and a spheroidal surface approximating the retina. By default, a matrix set is associated with a plaque: matrix set 1 is associated with plaque 1, matrix set 2 with plaque 2, and so on... When you switch from one plaque to another, the current matrix set is switched as well. This allows you to perform side-by-side dosimetric comparisons of different plaques and loadings.
If Auto. Update 2D Matrices is checked, the 2D matrices will update automatically in the background whenever a change occurs. For example, adding or removing a seed or moving the plaque would trigger an update. The calculation time for plaques that use seeds is generally fast enough that this feature can be enabled, but Ru plaques require a few seconds to calculate, and some large plaques with dozens of seeds may require significant time, so you may wish to leave auto updates disabled until you gain experience with the software.
Isodose plots of the 2D matrices can be displayed in the Dosimetry, Retinal Diagram, and Setup windows, and in several documents.